Long-Term Use of Acid Reflux Drugs Linked to Higher Risk of Dementia, Study Finds
Long-term use of acid reflux drugs has been found to increase the risk of developing dementia, according to a recent study. Acid reflux, which occurs when stomach acid enters the esophagus, can lead to heartburn, ulcers, and potentially esophageal cancer. To treat this condition, proton pump inhibitors (PPIs) are commonly used to lower stomach acid production by targeting the enzymes in the stomach lining.
While PPIs are effective in controlling acid reflux, previous studies have linked long-term use of these drugs to a higher risk of stroke, bone fractures, and chronic kidney disease. Now, a new study conducted by researchers from the University of Minnesota School of Public Health in Minneapolis has found a potential association between long-term PPI use and dementia.
The study, which included 5,712 participants aged 45 and older, initially did not have dementia. The researchers reviewed the participants’ medications during study visits and annual phone calls to determine if they were using acid reflux drugs. Of the participants, 26 percent (1,490 individuals) reported taking these drugs. The participants were then divided into four groups based on their usage duration: no drug usage, up to 2.8 years, 2.8 to 4.4 years, and more than 4.4 years.
The findings revealed that among the 4,222 participants who did not take the drugs, 415 people developed dementia, accounting for 19 cases per 1,000 person-years. However, among the 497 individuals who took the drugs for more than 4.4 years, 58 people developed dementia, resulting in 24 cases per 1,000 person-years. No higher risk of dementia was observed in those who used the drugs for less than 4.4 years.
Study author Kamakshi Lakshminarayan emphasized the need for further research to confirm these findings and explore the underlying reasons for the potential link between long-term PPI use and dementia. Lakshminarayan also advised individuals currently taking these medications to consult their doctors before making any changes, as abruptly stopping the drugs may worsen symptoms.
While there are alternative treatments for acid reflux, such as antacids and adopting a healthy lifestyle by maintaining a proper weight and avoiding late meals and certain foods, different approaches work for different people. It is thus important to seek professional medical advice to determine the best treatment plan.
In conclusion, this study adds to previous research suggesting a potential association between long-term use of acid reflux drugs and an increased risk of dementia. However, it is crucial to note that further research is needed to validate these findings and understand the underlying mechanisms.
