Neuroscientists at Scripps Research have discovered specific brain circuits that are activated when mammals are exposed to cold temperatures, leading to an increase in appetite and feeding. The researchers identified a cluster of neurons in mice that trigger this cold-induced, food-seeking behavior. The findings, published in the journal Nature, could potentially be used to develop therapeutics targeting these circuits to improve metabolic health and aid in weight loss. Cold exposure naturally causes mammals to burn more energy to maintain their body temperature, resulting in increased appetite. The study’s lead author highlighted the importance of understanding these brain circuits to enhance the metabolic benefits of cold exposure and fat burning. By uncovering the mechanism behind cold-induced appetite changes, future treatments may be developed to modulate these circuits and improve metabolic health in a safe and controlled manner.
Cold-Activated Brain Circuits Identified: Potential Therapeutics for Metabolic Health Discovered
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