A call to rethink the possible early cause of Alzheimer’s disease that challenges the accepted view of a build-up of amyloid proteins in the brain has come from QUT scientists. Researchers suggest a paradigm shift is needed to explore the ‘triggers’ behind toxic amyloid and tau proteins, with a focus on impaired adult hippocampal neurogenesis (AHN) as a potential early causal factor in Alzheimer’s disease. The study, published in Open Biology, indicates that AHN may diminish before amyloid and tau proteins appear, highlighting its initiating role in the early stages of AD development. The identification of disruptions and interactions within molecular pathways regulating AHN could lead to new insights into treating Alzheimer’s disease.
Researchers Challenge Traditional View of Alzheimer’s Disease Initiation and Offer New Approach, Australia
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