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Men's loss of the Y chromosome as they age can worsen cancer outcomes as it hinders their immune system's ability to fight cancer, according to new research. The study conducted by Cedars-Sinai Cancer discovered that aggressive bladder cancer is one of the cancers that result from this. Boosting the immune system may be less effective for men who lost their Y chromosome. Monitoring Y chromosome status may be useful in cancer treatment decisions. The research could lead to preventing or delaying Y chromosome loss.